I struggle with high cholesterol and I know I’m at risk of a heart attack if I don’t manage it correctly. It is no laughing matter. I’m taking the driver’s seat to See the Emergency in Cholesterol

— Jay Leno

After having two heart attacks, I realized that I needed to take further action to lower the risk of having another one. Now I’m working with my doctor and making the right lifestyle changes to reduce LDL-C and my risk of another heart attack.

— John

It's Time to
See the Emergency in Cholesterol

Adults in the United States with cardiovascular disease still have elevated LDL-Cholesterol despite using lipid-lowering therapy.

Ask your doctor if there are additional steps you can take to lower your LDL-C if…

You have a history of heart attack

You use maximally tolerated cholesterol-lowering therapy, and you are not reaching your goal previously set by your doctor

Ready to work with your doctor to learn how to lower your risk of another heart attack, but not sure where to start?

Download the doctor discussion guide to fill out and bring with you to your next doctor’s appointment.


Recognize the Risk
High LDL-C may have the strongest influence on your chance of having a heart attack

LDL-C, also known as bad cholesterol, is one of the most important risk factors for having a heart attack. Your risk for having a heart attack or stroke increases proportionally with higher bad cholesterol levels.

Bad cholesterol is the main cause of atherosclerosis – the formation of plaques in the arteries that can block the flow of blood, which increases your risk for major cardiovascular events, such as heart attack or stroke.

Find out about a treatment for patients who have had a heart attack and have high LDL cholesterol. LEARN MORE


For patients who have had a heart attack, when it comes to bad cholesterol, lower is better

Read more about John’s story and how he manages his high bad cholesterol after his second heart attack. READ JOHN’S STORY


High cholesterol is one of the most important risk factors associated with an increased risk of heart attack

If you’re working on lowering your risk for heart attack or stroke, taking a look at your risk factors can be a good place to start. A risk factor can be anything that has an influence on the likelihood of developing a disease or injury.

While there are many risk factors that may influence your chance of having a cardiovascular event, there are certain risk factors that are considered “modifiable,” meaning you can reduce their impact by taking action.

The INTERHEART study examined nine factors commonly associated with cardiovascular disease and their effect on the risk for having a heart attack. Of the nine factors investigated by the study, high cholesterol was most closely associated with an increased risk for heart attack.

Sign up to receive more information about how you can take control and lower your LDL-cholesterol.


“I have high cholesterol that thankfully I am able to control with the help of my doctor, but I’ve learned from some close friends about its connection to their heart attack. If you’ve had a heart attack and still have high cholesterol, now is the perfect time to talk with your doctor about additional treatment options to lower your cholesterol even more.”

— Jay Leno

Helpful information

High LDL-C is connected to a higher risk for heart attack or stroke.

A history of heart attack or stroke is the strongest predictor of a second event.

If your LDL-C is too high despite treatments, ask your doctor if there are additional steps you can take to lower your levels.


“Before my first heart attack, I wasn't aware my LDL levels were high. My doctor told me I needed to take action to address it because I’m at risk of a second attack.”

Additional Resources

These organizations provide resources for patients with cardiovascular disease. Learn more by clicking the logos below.

  • 1. Data on File, Amgen; 2018. 2. Grundy SM, et al. J Am Coll Cardiol. 2018; doi:10.1016/ j.jacc.2018.11.003. 3. Goldstein JL, et al. Arterioscler Thromb Vasc Biol. 2009;29(4):431-438. 4. Yusuf S, et al. Lancet. 2004;364:937-952. 5. Ference BA, et al. EHJ. 2017;38:2459-2472. 6. Glaglov S, et al. N Engl J Med. 1987;316(22):1371-1375. 7. Hansson GK. N Engl J Med. 2005;352:1685-1695. 8. Bhatt DL, et al. JAMA. 2010;304(12):1350-1357.